diff --git a/src/core/macros.ts b/src/core/macros.ts
index 2b6d7e9..c358e40 100644
--- a/src/core/macros.ts
+++ b/src/core/macros.ts
@@ -18,6 +18,7 @@ const DEFINE_PROPS = 'defineProps'
 const DEFINE_EMITS = 'defineEmits'
 const DEFINE_EXPOSE = 'defineExpose'
 const WITH_DEFAULTS = 'withDefaults'
+const DEFINE_SLOTS = 'defineSlots'
 
 export interface PropTypeData {
   key: string
@@ -28,6 +29,7 @@ export interface PropTypeData {
 export function applyMacros(nodes: Statement[]) {
   let hasDefinePropsCall = false
   let hasDefineEmitCall = false
+  let hasDefineSlotsCall = false
   let propsRuntimeDecl: Node | undefined
   let propsRuntimeDefaults: Node | undefined
   let propsTypeDecl: TSTypeLiteral | TSInterfaceBody | undefined
@@ -204,6 +206,23 @@ export function applyMacros(nodes: Statement[]) {
     return true
   }
 
+  function processDefineSlots(
+    node: Node,
+  ): boolean {
+    if (!isCallOf(node, DEFINE_SLOTS))
+      return false
+
+    if (hasDefineSlotsCall)
+      error(`duplicate ${DEFINE_SLOTS}() call`, node)
+
+    hasDefineSlotsCall = true
+
+    if (node.arguments.length > 0)
+      error(`${DEFINE_SLOTS}() cannot accept arguments`, node)
+
+    return true
+  }
+
   function genRuntimeProps(props: Record<string, PropTypeData>) {
     const keys = Object.keys(props)
     if (!keys.length)
@@ -270,7 +289,9 @@ export function applyMacros(nodes: Statement[]) {
           const decl = node.declarations[i]
           if (decl.init) {
             if (processDefineEmits(decl.init))
-              decl.init = t.memberExpression(t.identifier('__ctx'), t.identifier('emit')) as any
+              decl.init = t.memberExpression(t.identifier('__ctx'), t.identifier('emit'))
+            else if (processDefineSlots(decl.init))
+              decl.init = t.memberExpression(t.identifier('__ctx'), t.identifier('slots'))
             else if (processDefineProps(decl.init) || processWithDefaults(decl.init))
               decl.init = t.identifier('__props') as any
             else
@@ -279,7 +300,7 @@ export function applyMacros(nodes: Statement[]) {
         }
       }
 
-      if (processWithDefaults(node) || processDefineEmits(node) || processDefineProps(node) || processDefineExpose(node))
+      if (processWithDefaults(node) || processDefineEmits(node) || processDefineProps(node) || processDefineExpose(node) || processDefineSlots(node))
         return null
 
       throwIfAwait(node)
diff --git a/test/__snapshots__/transform.test.ts.snap b/test/__snapshots__/transform.test.ts.snap
index 821b14b..80c2d32 100644
--- a/test/__snapshots__/transform.test.ts.snap
+++ b/test/__snapshots__/transform.test.ts.snap
@@ -677,6 +677,36 @@ export default __sfc_main;
 "
 `;
 
+exports[`transform > fixtures > test/fixtures/MacrosType5.vue 1`] = `
+"<script lang=\\"ts\\">
+const __sfc_main = {};
+export default __sfc_main;
+</script>
+"
+`;
+
+exports[`transform > fixtures > test/fixtures/MacrosType6.vue 1`] = `
+"<script lang=\\"ts\\">
+const __sfc_main = {};
+__sfc_main.setup = (__props, __ctx) => {
+  const slots = __ctx.slots;
+  return {
+    slots
+  };
+};
+export default __sfc_main;
+</script>
+<template>
+  <template v-if=\\"slots.default\\">
+    <slot name=\\"default\\" msg=\\"hello\\"></slot>
+  </template>
+  <div v-else>
+    fallback
+  </div>
+</template>
+"
+`;
+
 exports[`transform > fixtures > test/fixtures/MacrosTypeAny.vue 1`] = `
 "<template>
   <div>
diff --git a/test/fixtures/MacrosType5.vue b/test/fixtures/MacrosType5.vue
new file mode 100644
index 0000000..d0d5475
--- /dev/null
+++ b/test/fixtures/MacrosType5.vue
@@ -0,0 +1,5 @@
+<script setup lang="ts">
+defineSlots<{
+  default: { msg: string }
+}>()
+</script>
diff --git a/test/fixtures/MacrosType6.vue b/test/fixtures/MacrosType6.vue
new file mode 100644
index 0000000..22f0e34
--- /dev/null
+++ b/test/fixtures/MacrosType6.vue
@@ -0,0 +1,13 @@
+<script setup lang="ts">
+const slots = defineSlots<{
+  default: { msg: string }
+}>()
+</script>
+<template>
+  <template v-if="slots.default">
+    <slot name="default" msg="hello"></slot>
+  </template>
+  <div v-else>
+    fallback
+  </div>
+</template>