diff --git a/packages/sqlite_async/lib/src/common/sqlite_database.dart b/packages/sqlite_async/lib/src/common/sqlite_database.dart
index 3cb12bb..3201135 100644
--- a/packages/sqlite_async/lib/src/common/sqlite_database.dart
+++ b/packages/sqlite_async/lib/src/common/sqlite_database.dart
@@ -39,6 +39,14 @@ mixin SqliteDatabaseMixin implements SqliteConnection, SqliteQueries {
   ///
   /// Use this to access the database in background isolates.
   IsolateConnectionFactory isolateConnectionFactory();
+
+  /// Locks all underlying connections making up this database, and gives [block] access to all of them at once.
+  /// This can be useful to run the same statement on all connections. For instance,
+  /// ATTACHing a database, that is expected to be available in all connections.
+  Future<T> withAllConnections<T>(
+      Future<T> Function(
+              SqliteWriteContext writer, List<SqliteReadContext> readers)
+          block);
 }
 
 /// A SQLite database instance.
diff --git a/packages/sqlite_async/lib/src/impl/single_connection_database.dart b/packages/sqlite_async/lib/src/impl/single_connection_database.dart
index 4cd3144..7ca4357 100644
--- a/packages/sqlite_async/lib/src/impl/single_connection_database.dart
+++ b/packages/sqlite_async/lib/src/impl/single_connection_database.dart
@@ -57,4 +57,12 @@ final class SingleConnectionDatabase
     return connection.writeLock(callback,
         lockTimeout: lockTimeout, debugContext: debugContext);
   }
+
+  @override
+  Future<T> withAllConnections<T>(
+      Future<T> Function(
+              SqliteWriteContext writer, List<SqliteReadContext> readers)
+          block) {
+    return writeLock((_) => block(connection, []));
+  }
 }
diff --git a/packages/sqlite_async/lib/src/impl/stub_sqlite_database.dart b/packages/sqlite_async/lib/src/impl/stub_sqlite_database.dart
index 29db641..ee254f3 100644
--- a/packages/sqlite_async/lib/src/impl/stub_sqlite_database.dart
+++ b/packages/sqlite_async/lib/src/impl/stub_sqlite_database.dart
@@ -64,4 +64,12 @@ class SqliteDatabaseImpl
   Future<bool> getAutoCommit() {
     throw UnimplementedError();
   }
+
+  @override
+  Future<T> withAllConnections<T>(
+      Future<T> Function(
+              SqliteWriteContext writer, List<SqliteReadContext> readers)
+          block) {
+    throw UnimplementedError();
+  }
 }
diff --git a/packages/sqlite_async/lib/src/native/database/connection_pool.dart b/packages/sqlite_async/lib/src/native/database/connection_pool.dart
index 9521b34..8dab27e 100644
--- a/packages/sqlite_async/lib/src/native/database/connection_pool.dart
+++ b/packages/sqlite_async/lib/src/native/database/connection_pool.dart
@@ -31,6 +31,8 @@ class SqliteConnectionPool with SqliteQueries implements SqliteConnection {
 
   final MutexImpl mutex;
 
+  int _runningWithAllConnectionsCount = 0;
+
   @override
   bool closed = false;
 
@@ -88,6 +90,14 @@ class SqliteConnectionPool with SqliteQueries implements SqliteConnection {
       return;
     }
 
+    if (_availableReadConnections.isEmpty &&
+        _runningWithAllConnectionsCount > 0) {
+      // Wait until [withAllConnections] is done. Otherwise we could spawn a new
+      // reader while the user is configuring all the connections,
+      // e.g. a global open factory configuration shared across all connections.
+      return;
+    }
+
     var nextItem = _queue.removeFirst();
     while (nextItem.completer.isCompleted) {
       // This item already timed out - try the next one if available
@@ -232,6 +242,66 @@ class SqliteConnectionPool with SqliteQueries implements SqliteConnection {
       await connection.refreshSchema();
     }
   }
+
+  Future<T> withAllConnections<T>(
+      Future<T> Function(
+              SqliteWriteContext writer, List<SqliteReadContext> readers)
+          block) async {
+    try {
+      _runningWithAllConnectionsCount++;
+
+      final blockCompleter = Completer<T>();
+      final (write, reads) = await _lockAllConns<T>(blockCompleter);
+
+      try {
+        final res = await block(write, reads);
+        blockCompleter.complete(res);
+        return res;
+      } catch (e, st) {
+        blockCompleter.completeError(e, st);
+        rethrow;
+      }
+    } finally {
+      _runningWithAllConnectionsCount--;
+
+      // Continue processing any pending read requests that may have been queued while
+      // the block was running.
+      Timer.run(_nextRead);
+    }
+  }
+
+  /// Locks all connections, returning the acquired contexts.
+  /// We pass a completer that would be called after the locks are taken.
+  Future<(SqliteWriteContext, List<SqliteReadContext>)> _lockAllConns<T>(
+      Completer<T> lockCompleter) async {
+    final List<Completer<SqliteReadContext>> readLockedCompleters = [];
+    final Completer<SqliteWriteContext> writeLockedCompleter = Completer();
+
+    // Take the write lock
+    writeLock((ctx) {
+      writeLockedCompleter.complete(ctx);
+      return lockCompleter.future;
+    });
+
+    // Take all the read locks
+    for (final readConn in _allReadConnections) {
+      final completer = Completer<SqliteReadContext>();
+      readLockedCompleters.add(completer);
+
+      readConn.readLock((ctx) {
+        completer.complete(ctx);
+        return lockCompleter.future;
+      });
+    }
+
+    // Wait after all locks are taken
+    final [writer as SqliteWriteContext, ...readers] = await Future.wait([
+      writeLockedCompleter.future,
+      ...readLockedCompleters.map((e) => e.future)
+    ]);
+
+    return (writer, readers);
+  }
 }
 
 typedef ReadCallback<T> = Future<T> Function(SqliteReadContext tx);
diff --git a/packages/sqlite_async/lib/src/native/database/native_sqlite_database.dart b/packages/sqlite_async/lib/src/native/database/native_sqlite_database.dart
index 7bea111..22cacf3 100644
--- a/packages/sqlite_async/lib/src/native/database/native_sqlite_database.dart
+++ b/packages/sqlite_async/lib/src/native/database/native_sqlite_database.dart
@@ -171,4 +171,12 @@ class SqliteDatabaseImpl
   Future<void> refreshSchema() {
     return _pool.refreshSchema();
   }
+
+  @override
+  Future<T> withAllConnections<T>(
+      Future<T> Function(
+              SqliteWriteContext writer, List<SqliteReadContext> readers)
+          block) {
+    return _pool.withAllConnections(block);
+  }
 }
diff --git a/packages/sqlite_async/lib/src/web/database.dart b/packages/sqlite_async/lib/src/web/database.dart
index cfaf987..f2dc998 100644
--- a/packages/sqlite_async/lib/src/web/database.dart
+++ b/packages/sqlite_async/lib/src/web/database.dart
@@ -171,6 +171,14 @@ class WebDatabase
     await isInitialized;
     return _database.fileSystem.flush();
   }
+
+  @override
+  Future<T> withAllConnections<T>(
+      Future<T> Function(
+              SqliteWriteContext writer, List<SqliteReadContext> readers)
+          block) {
+    return writeLock((_) => block(this, []));
+  }
 }
 
 final class _UnscopedContext extends UnscopedContext {
diff --git a/packages/sqlite_async/lib/src/web/database/web_sqlite_database.dart b/packages/sqlite_async/lib/src/web/database/web_sqlite_database.dart
index c6d1b75..69f01ab 100644
--- a/packages/sqlite_async/lib/src/web/database/web_sqlite_database.dart
+++ b/packages/sqlite_async/lib/src/web/database/web_sqlite_database.dart
@@ -178,4 +178,12 @@ class SqliteDatabaseImpl
   Future<WebDatabaseEndpoint> exposeEndpoint() async {
     return await _connection.exposeEndpoint();
   }
+
+  @override
+  Future<T> withAllConnections<T>(
+      Future<T> Function(
+              SqliteWriteContext writer, List<SqliteReadContext> readers)
+          block) {
+    return writeLock((_) => block(_connection, []));
+  }
 }
diff --git a/packages/sqlite_async/test/basic_test.dart b/packages/sqlite_async/test/basic_test.dart
index 6a315da..e2914b3 100644
--- a/packages/sqlite_async/test/basic_test.dart
+++ b/packages/sqlite_async/test/basic_test.dart
@@ -7,6 +7,7 @@ import 'utils/test_utils_impl.dart';
 
 final testUtils = TestUtils();
 const _isDart2Wasm = bool.fromEnvironment('dart.tool.dart2wasm');
+const _isWeb = identical(0, 0.0) || _isDart2Wasm;
 
 void main() {
   group('Shared Basic Tests', () {
@@ -301,6 +302,49 @@ void main() {
         'Web locks are managed with a shared worker, which does not support timeouts',
       )
     });
+
+    test('with all connections', () async {
+      final maxReaders = _isWeb ? 0 : 3;
+
+      final db = SqliteDatabase.withFactory(
+        await testUtils.testFactory(path: path),
+        maxReaders: maxReaders,
+      );
+      await db.initialize();
+      await createTables(db);
+
+      // Warm up to spawn the max readers
+      await Future.wait([for (var i = 0; i < 10; i++) db.get('SELECT $i')]);
+
+      bool finishedWithAllConns = false;
+
+      late Future<void> readsCalledWhileWithAllConnsRunning;
+
+      final parentZone = Zone.current;
+      await db.withAllConnections((writer, readers) async {
+        expect(readers.length, maxReaders);
+
+        // Run some reads during the block that they should run after the block finishes and releases
+        // all locks
+        // Need a root zone here to avoid recursive lock errors.
+        readsCalledWhileWithAllConnsRunning =
+            Future(parentZone.bindCallback(() async {
+          await Future.wait(
+            [1, 2, 3, 4, 5, 6, 7, 8].map((i) async {
+              await db.readLock((c) async {
+                expect(finishedWithAllConns, isTrue);
+                await Future.delayed(const Duration(milliseconds: 100));
+              });
+            }),
+          );
+        }));
+
+        await Future.delayed(const Duration(milliseconds: 200));
+        finishedWithAllConns = true;
+      });
+
+      await readsCalledWhileWithAllConnsRunning;
+    });
   });
 }
 
diff --git a/packages/sqlite_async/test/native/basic_test.dart b/packages/sqlite_async/test/native/basic_test.dart
index dec1fed..3f348e6 100644
--- a/packages/sqlite_async/test/native/basic_test.dart
+++ b/packages/sqlite_async/test/native/basic_test.dart
@@ -2,12 +2,16 @@
 library;
 
 import 'dart:async';
+import 'dart:io';
 import 'dart:math';
 
+import 'package:collection/collection.dart';
+import 'package:path/path.dart' show join;
 import 'package:sqlite3/common.dart' as sqlite;
 import 'package:sqlite_async/sqlite_async.dart';
 import 'package:test/test.dart';
 
+import '../utils/abstract_test_utils.dart';
 import '../utils/test_utils_impl.dart';
 
 final testUtils = TestUtils();
@@ -100,6 +104,126 @@ void main() {
       print("${DateTime.now()} done");
     });
 
+    test('prevent opening new readers while in withAllConnections', () async {
+      final sharedStateDir = Directory.systemTemp.createTempSync();
+      addTearDown(() => sharedStateDir.deleteSync(recursive: true));
+
+      final File sharedStateFile =
+          File(join(sharedStateDir.path, 'shared-state.txt'));
+
+      sharedStateFile.writeAsStringSync('initial');
+
+      final db = SqliteDatabase.withFactory(
+          _TestSqliteOpenFactoryWithSharedStateFile(
+              path: path, sharedStateFilePath: sharedStateFile.path),
+          maxReaders: 3);
+      await db.initialize();
+      await createTables(db);
+
+      // The writer saw 'initial' in the file when opening the connection
+      expect(
+        await db
+            .writeLock((c) => c.get('SELECT file_contents_on_open() AS state')),
+        {'state': 'initial'},
+      );
+
+      final withAllConnectionsCompleter = Completer<void>();
+
+      final withAllConnsFut = db.withAllConnections((writer, readers) async {
+        expect(readers.length, 0); // No readers yet
+
+        // Simulate some work until the file is updated
+        await Future.delayed(const Duration(milliseconds: 200));
+        sharedStateFile.writeAsStringSync('updated');
+
+        await withAllConnectionsCompleter.future;
+      });
+
+      // Start a reader that gets the contents of the shared file
+      bool readFinished = false;
+      final someReadFut =
+          db.get('SELECT file_contents_on_open() AS state', []).then((r) {
+        readFinished = true;
+        return r;
+      });
+
+      // The withAllConnections should prevent the reader from opening
+      await Future.delayed(const Duration(milliseconds: 100));
+      expect(readFinished, isFalse);
+
+      // Free all the locks
+      withAllConnectionsCompleter.complete();
+      await withAllConnsFut;
+
+      final readerInfo = await someReadFut;
+      expect(readFinished, isTrue);
+      // The read should see the updated value in the file. This checks
+      // that a reader doesn't spawn while running withAllConnections
+      expect(readerInfo, {'state': 'updated'});
+    });
+
+    test('with all connections', () async {
+      final maxReaders = 3;
+
+      final db = SqliteDatabase.withFactory(
+        await testUtils.testFactory(path: path),
+        maxReaders: maxReaders,
+      );
+      await db.initialize();
+      await createTables(db);
+
+      Future<sqlite.Row> readWithRandomDelay(
+          SqliteReadContext ctx, int id) async {
+        return await ctx.get(
+            'SELECT ? as i, test_sleep(?) as sleep, test_connection_name() as connection',
+            [id, 5 + Random().nextInt(10)]);
+      }
+
+      // Warm up to spawn the max readers
+      await Future.wait(
+        [1, 2, 3, 4, 5, 6, 7, 8].map((i) => readWithRandomDelay(db, i)),
+      );
+
+      bool finishedWithAllConns = false;
+
+      late Future<void> readsCalledWhileWithAllConnsRunning;
+
+      print("${DateTime.now()} start");
+      await db.withAllConnections((writer, readers) async {
+        expect(readers.length, maxReaders);
+
+        // Run some reads during the block that they should run after the block finishes and releases
+        // all locks
+        readsCalledWhileWithAllConnsRunning = Future.wait(
+          [1, 2, 3, 4, 5, 6, 7, 8].map((i) async {
+            final r = await db.readLock((c) async {
+              expect(finishedWithAllConns, isTrue);
+              return await readWithRandomDelay(c, i);
+            });
+            print(
+                "${DateTime.now()} After withAllConnections, started while running $r");
+          }),
+        );
+
+        await Future.wait([
+          writer.execute(
+              "INSERT OR REPLACE INTO test_data(id, description) SELECT ? as i, test_sleep(?) || ' ' || test_connection_name() || ' 1 ' || datetime() as connection RETURNING *",
+              [
+                123,
+                5 + Random().nextInt(20)
+              ]).then((value) =>
+              print("${DateTime.now()} withAllConnections writer done $value")),
+          ...readers
+              .mapIndexed((i, r) => readWithRandomDelay(r, i).then((results) {
+                    print(
+                        "${DateTime.now()} withAllConnections readers done $results");
+                  }))
+        ]);
+      }).then((_) => finishedWithAllConns = true);
+
+      await readsCalledWhileWithAllConnsRunning;
+    });
+
     test('read-only transactions', () async {
       final db = await testUtils.setupDatabase(path: path);
       await createTables(db);
@@ -379,3 +503,31 @@ class _InvalidPragmaOnOpenFactory extends DefaultSqliteOpenFactory {
     ];
   }
 }
+
+class _TestSqliteOpenFactoryWithSharedStateFile
+    extends TestDefaultSqliteOpenFactory {
+  final String sharedStateFilePath;
+
+  _TestSqliteOpenFactoryWithSharedStateFile(
+      {required super.path, required this.sharedStateFilePath});
+
+  @override
+  sqlite.CommonDatabase open(SqliteOpenOptions options) {
+    final File sharedStateFile = File(sharedStateFilePath);
+    final String sharedState = sharedStateFile.readAsStringSync();
+
+    final db = super.open(options);
+
+    // Function to return the contents of the shared state file at the time of opening
+    // so that we know at which point the factory was called.
+    db.createFunction(
+      functionName: 'file_contents_on_open',
+      argumentCount: const sqlite.AllowedArgumentCount(0),
+      function: (args) {
+        return sharedState;
+      },
+    );
+
+    return db;
+  }
+}