diff --git a/sentry_sdk/integrations/chalice.py b/sentry_sdk/integrations/chalice.py
index ade1c7f10f..e7d2777b53 100644
--- a/sentry_sdk/integrations/chalice.py
+++ b/sentry_sdk/integrations/chalice.py
@@ -2,7 +2,7 @@
 
 from sentry_sdk._compat import reraise
 from sentry_sdk.hub import Hub
-from sentry_sdk.integrations import Integration
+from sentry_sdk.integrations import Integration, DidNotEnable
 from sentry_sdk.integrations.aws_lambda import _make_request_event_processor
 from sentry_sdk.utils import (
     capture_internal_exceptions,
@@ -22,6 +22,11 @@
 
     F = TypeVar("F", bound=Callable[..., Any])
 
+try:
+    from chalice import __version__ as CHALICE_VERSION
+except ImportError:
+    raise DidNotEnable("Chalice is not installed")
+
 
 class EventSourceHandler(ChaliceEventSourceHandler):  # type: ignore
     def __call__(self, event, context):
@@ -36,8 +41,7 @@ def __call__(self, event, context):
                     _make_request_event_processor(event, context, configured_time)
                 )
             try:
-                event_obj = self.event_class(event, context)
-                return self.func(event_obj)
+                return ChaliceEventSourceHandler.__call__(self, event, context)
             except Exception:
                 exc_info = sys.exc_info()
                 event, hint = event_from_exception(
@@ -92,7 +96,18 @@ class ChaliceIntegration(Integration):
     @staticmethod
     def setup_once():
         # type: () -> None
-        old_get_view_function_response = Chalice._get_view_function_response
+        try:
+            version = tuple(map(int, CHALICE_VERSION.split(".")[:3]))
+        except (ValueError, TypeError):
+            raise DidNotEnable("Unparsable Chalice version: {}".format(CHALICE_VERSION))
+        if version < (1, 20):
+            old_get_view_function_response = Chalice._get_view_function_response
+        else:
+            from chalice.app import RestAPIEventHandler
+
+            old_get_view_function_response = (
+                RestAPIEventHandler._get_view_function_response
+            )
 
         def sentry_event_response(app, view_function, function_args):
             # type: (Any, F, **Any) -> Any
@@ -104,6 +119,9 @@ def sentry_event_response(app, view_function, function_args):
                 app, wrapped_view_function, function_args
             )
 
-        Chalice._get_view_function_response = sentry_event_response
+        if version < (1, 20):
+            Chalice._get_view_function_response = sentry_event_response
+        else:
+            RestAPIEventHandler._get_view_function_response = sentry_event_response
         # for everything else (like events)
         chalice.app.EventSourceHandler = EventSourceHandler
diff --git a/tox.ini b/tox.ini
index eb85a4b654..331dc0c192 100644
--- a/tox.ini
+++ b/tox.ini
@@ -77,7 +77,7 @@ envlist =
 
     {py3.5,py3.6,py3.7,py3.8,py3.9}-pure_eval
 
-    {py3.6,py3.7,py3.8}-chalice-{1.16,1.17,1.18,1.19}
+    {py3.6,py3.7,py3.8}-chalice-{1.16,1.17,1.18,1.19,1.20}
 
 [testenv]
 deps =
@@ -204,6 +204,7 @@ deps =
     chalice-1.17: chalice>=1.17.0,<1.18.0
     chalice-1.18: chalice>=1.18.0,<1.19.0
     chalice-1.19: chalice>=1.19.0,<1.20.0
+    chalice-1.20: chalice>=1.20.0,<1.21.0
     chalice: pytest-chalice==0.0.5
 
 setenv =