mixins.ts

// Disposable Mixin
class Disposable {
    isDisposed: boolean;
    dispose() {
        this.isDisposed = true;
    }

}
 
// Activatable Mixin
class Activatable {
    isActive: boolean;
    activate() {
        this.isActive = true;
    }
    deactivate() {
        this.isActive = false;
    }
}

interface ActivatibleDisposible extends Disposable, Activatable {
    new (): ActivatibleDisposible;
}

var ActivatibleDisposible: ActivatibleDisposible = <any>(function(){
    Disposable.apply(this);
    ActivatibleDisposible.apply(this);
    return this;
})

class SmartObject extends ActivatibleDisposible {
    constructor() {
        super();
        setInterval(() => console.log(this.isActive + " : " + this.isDisposed), 500);
    }

    interact() {
        this.activate();
    }
}
applyMixins(SmartObject, [Disposable, Activatable])

var smartObj = new SmartObject();
setTimeout(() => smartObj.interact(), 1000);
 
////////////////////////////////////////
// In your runtime library somewhere
////////////////////////////////////////

function applyMixins(derivedCtor: any, baseCtors: any[]) {
    baseCtors.forEach(baseCtor => {
        Object.getOwnPropertyNames(baseCtor.prototype).forEach(name => {
            derivedCtor.prototype[name] = baseCtor.prototype[name];
        })
    });
}